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Probably, in COPD, oral antioxidants or inhaled corticosteroids alone are not sufficient to reduce oxidative stress and inflammation

GSH delivery could be improved by some derivatives with hydrophobic chains of different length or by I-152, which is a conjugate of NAC and s-acetyl--mercaptoethylamine (MEA), which is able to release NAC and MEA and increase GSH content [100]

Induction of gp130-related cytokines and activation of JAK2/STAT3 pathway in astrocytes precedes up-regulation of glial fibrillary acidic protein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of neurodegeneration: key signaling pathway for astrogliosis in vivo

Similarly, another trial confirmed the safety of CoQ 10 at high doses but failed to show statistically significant improvements (208)