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Clin Sci (Lond) (2018) 132(22):240722
24 h and 48 h after application) strongly reduced tumor mass
This decline is closely correlated with the loss of tissue regenerative capacity, increased inflammation, and accelerated skin aging
Similarly, in ISO-induced hypertrophic cardiomyopathy models, CYP2E1 overexpression increased susceptibility to cardiac hypertrophy and accelerated decompensation, whereas CYP2E1 deficiency reduced the response to ISO treatment and significantly alleviated myocardial remodeling
