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The STEP 4 withdrawal trial demonstrated that continued Semaglutide therapy was needed to maintain weight loss, as patients switched to placebo regained weight over 48 weeks (Rubino et al., JAMA 2021
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Although Tsc1 deficiency does not fundamentally affect the formation of effector CD8 + T cell responses, the memory precursor effector cell population is affected by Tsc1 deficiency
