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In support of the theory that SOD1 aggregation may be linked to problems with metalation, a study utilizing NMR spectroscopy to investigate the structure of fully metalated wild-type SOD1 and the G93A SOD1 variant found this mutation resulted in local destabilization of protein structure at the site of the mutation, but more importantly selectively destabilized the metal binding region of SOD1 (Museth et al., 2009)
4 A systematic review of the effectiveness and cost-effectiveness of neuroimaging assessments used to visualise the seizure focus in people with refractory epilepsy being considered for surgery
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The Role of B12 in Fat Breakdown vs
