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Scientific interest includes: Biological age reduction Cellular rejuvenation Tissue regeneration Healthspan extension Age-related degeneration research Animal models continue to explore the relationship between senescent cell clearance and healthy aging

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Furin is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at the Golgi 15 , allowing efficient GNPT cleavage in the absence of LYSET (Fig

This enabled the recognition of M7M10 as a structurally coherent cluster derived from sequential O -demethylenation, subsequent hydroxylation, and O -methylation of M1, metabolites that would likely have been missed in a standard targeted workflow due to the difficulty of anticipating multi-step biotransformation products a priori