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Since we found a down regulation of pro-angiogenic factors VEGF, CXCL8 in PCa cells and chemokine receptors (CXCR1/2, CXCR4, CCR2) on endothelial cells, we assessed whether ALCAR 1 or 10 mM, would affect PCa cellc pro-angiogenic products release and consequently interfere with the ability of endothelial cells to functionally induce cell morphogenesis

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Irinotecan has shown limited efficacy due to low BBB penetration

As a nutrient, L-Carnitine is not one of those components that we can define essential or essential, as the body could typically be able to survive without it