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Roles of bile acids signaling in neuromodulation under physiological and pathological conditions

For example, metabolic disorders like type 2 diabetes involve a complex interplay between pancreatic, hepatic, adipose, and immune cells (187), while cancer progression and drug resistance are increasingly linked to interactions between tumor cells, stromal fibroblasts, immune infiltrates, and endothelial components (188, 189)

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Laliberte RE, Perregaux DG, Hoth LR, Rosner PJ, Jordan CK, Peese KM, Eggler JF, Dombroski MA, Geoghegan KF, Gabel CA: Glutathione s-transferase omega 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1beta posttranslational processing