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doi: 10.1016/j.chembiol.2019.02.003 106 TawarayamaHUmekiKInoue-YanagimachiMTakahashiNHasegawaHHimoriNet al

Practitioner reports place early symptom changes in weeks 12, functional changes around weeks 34, and structural remodeling through weeks 812

And that's true at physiological levels

M.2006Human arsenic methyltransferase (AS3MT) pharmacogenetics: gene resequencing and functional genomics studies.28111(March 2006),73647373,0021-9258 121
