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Inhibition of NNMT rebalances cellular methyl economy and NAD salvage flux, with downstream effects on adipocyte energetics, lipid handling, and insulin action observed in preclinical systems [13]

The Phase 2 trial is the only controlled human efficacy study

Applications in the Exploration of Obesity Intervention Strategies and Drug Development Based on its unique mechanism of action and favorable physiological regulatory effects, NNMTi has become an important candidate molecule for the exploration of obesity intervention strategies and the development of antiobesity drugs

B12 is essential for red blood cell formation, neurological function, and DNA synthesis