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However, further evaluation of their brain penetration ability using a cellular BBB model is required to advance preclinical testing

doi: 10.1038/nature13193

3.8 Mitochondrial disfunction and mtDNA therapy Mitochondria are essential organelles that are involved in IIS response via release of ROS and mtDNA and contribute to the pathogen-associated ASCVD development [89]

Pharmacological interventions such as orlistat or GLP-1 receptor agonists may be considered for patients with BMI 30 kg/m who have not achieved adequate weight loss through lifestyle measures alone
