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In TJA, where the consequences of wound failure and PJI are severe, the absence of validated safety data is clinically meaningful
J Clin Invest 100: 350356
However, oxidative stress is proposed as one of the underlining pathology
Although the time course of Nrf2 stabilization and nuclear translocation indicated a rapid increase with a peak at approximately 6 h for DEM, and a slow but gradual rise triggered by NFT, maximal accumulation of Nrf2 protein, as well as the induction of GCLC and glutathione synthesis, were almost identical for both NFT and DEM after incubation periods of and beyond 24 h (Fig
