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Moreover, CuATSM demonstrates selective cytotoxicity towards DIPG through mechanisms intricately associated with generating H 2 O 2 and copper involvement

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With the sub-toxic dose of 0.1 mM, the low gradient of 40 is temporary, with cells rapidly starting to recover the Tpx1-driven gradient of 300, while with the toxic dose of 0.5 mM the gradient collapse is much more sustained and does not recover even after 50 min

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