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Upon activation of the intrinsic apoptotic pathway, expression of Bcl-2 is suppressed while that of Bax increases, leading to the opening of the permeability transition pores (PTP), enhanced mitochondrial membrane permeability, loss of mitochondrial membrane potential, and the release of apoptotic proteins such as cytochrome C (Cyt-c) and DIABLO/Smac into the cytosol

Seminars in immunology : Elsevier

P., Chaible L

The biological characteristics of DCs can be divided into two key stages: immature DCs possess remarkable tissue migration ability and antigen capture efficiency, while mature DCs, through high expression of antigen-presenting molecules and co-stimulatory molecules, specifically activate naive T lymphocytes, thereby playing a core hub role in the initiation, regulation, and maintenance of the immune response (78)
