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Domestic refrigerators may not maintain consistent temperatures and are not equivalent to pharmaceutical cold storage

The findings of these studies reported a significant decrease in the research models body weight and adipose tissue accumulation subsequent to the intervention

To avoid a potential risk of hypercobalaminemia or possible health risks of high-dose dietary supplements, an annual blood test is recommended, after which targeted substitution can be performed
A small number of double-blind, placebo-controlled clinical trials, with a degree of variability in enrollment criteria, intervention, and outcome measures, have been conducted to test whether additional antibiotics are effective (135, 154, 155)
