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There are no health benefits to these dogs at all." Mr Adam later said that while he would "like to have dogs' ears removed" it was illegal and he had "never arranged for it to be done"

Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis

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FIGURE 1 Animals were fed either Research Diet D12492 (HFD) or D12450j (LFD) (Research Diets, New Brunswick NJ) and treated with daily intraperitoneal injections of 8 mg/kg rapamycin (LC Laboratories, Woburn MA) (cohort 1 and 2), daily intraperitoneal injections of 2.5 mg/kg, 5 mg/kg, 10 mg/kg, or 25 mg/kg adefovir dipivoxil (cohorts 2 and 3) (Carbosynth, UK), or with adefovir dipivoxil mixed in the chow for 6 weeks at 21 mg/kg, 42 mg/kg, 84 mg/kg, or 210 mg/kg w/w (cohorts 2 and 3)