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Challenges Related to Substrate Complexity Mushroom residuals, particularly spent mushroom substrate (SMS), constitute complex mixtures that present specific technical challenges for ergothioneine extraction and purification

[Google Scholar] 217.Prasad R., Lakshmi A.V., Bamji M.S

Future success will depend on biomarker-guided patient stratification (e.g., using imaging and fluid biomarkers) combined with stage-adapted interventions, whether through refined chelation protocols, multimodal approaches, or novel delivery systems designed to navigate the unique pathophysiology of the AD brain