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Description
Human systemic dosing is not established
This study, where 2586 patients were treated with either rofecoxib or placebo, inferred that long term use of rofecoxib is associated with twice the risk of heart attack or stroke versus placebo [118], [119]
Lee SL, Hsu JY, Chen TC, Huang CC, Wu TY, Chin TY
However, the retinal vasculature and cerebral vasculature share the same embryonic origin, and many similarities have been found in the pathologies affecting the two tissues
