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Notably, a proteomic approach identified a set of nitrated proteins, including -enolase, H + -transporting ATPase, and peroxiredoxin-2 in the brains of both Mild Cognitive Impairment (MCI) and AD patients [77]

Cognitive function or cognition as used herein refers to a range of high-level brain functions, including but not limited to: the ability to learn and remember information

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To better understand considerations on patient monitoring and management pertaining to aminotransferase elevations in patients who receive omaveloxolone, we: (1) review the mechanistic insights behind Nrf2 activation by omaveloxolone that result in induction of aminotransferases