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Increased magnetic susceptibility in hippocampal and cortical regions is associated with cognitive severity at a single timepoint 62,171 , and increased susceptibility in the nucleus basalis of Meynert is predictive of poorer cognitive performance after follow-up 172

Accumulation of SAH can impair transmethylation reactions by allosteric inhibition of methyltransferases

343 According to a 2020 systematic review and meta-analysis that included 60 randomized controlled trials with a total of 4,129 patients, omega-3 fatty acid supplementation appeared to decrease the incidence of cardiovascular death by 55% in CKD patients on hemodialysis, though it did not appear to reduce mortality overall

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