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Inhibiting GAPDH in highly glycolytic KRAS or BRAF mutant cells ultimately led to an energy crisis and cell death not seen in their KRAS and BRAF wild-type counterparts

Forbes JM, Thorburn DR

Erk5 is downstream of Erk1/2 but both are regulated by growth factors through activation of upstream Ras

21 Watanabe et al also demonstrated that topically applied GSSG can significantly reduce melanin indices
