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The mechanism mainly involves increased androgen synthesis in the ovaries and adrenal glands, along with a decrease in sex hormone-binding globulin (SHBG) levels, further increasing free androgen bioavailability ( Figure 2 )
Free Rad Biol Med 82:2228 No W, Mollenschott C, Berlin J (1984) Tryptophan decarboxylase from Catharanthus roseus cell suspension cultures: purification, molecular and kinetic data of the homogenous protein
