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No participants withdrew from any trial due to tolerability issues, indicating that even when side effects occurred, they were sufficiently manageable that participants chose to continue treatment

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Various required total sample sizes according to meaningful differences and powers of 80% and 90% are depicted in figure 2

In addition, it has been shown that pancreas resected patients need higher amount of vitamin D supplementation to reach serum 25(OH)D concentrations in range between 30 and 50 ng/ml 5