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however the mechanism for these actions is still unclear

Tang X, Li Y, Liu L, Guo R, Zhang P, Zhang Y, Zhang Y, Zhao J, Su J, Sun L, Liu Y (2020) Sirtuin 3 induces apoptosis and necroptosis by regulating mutant p53 expression in small-cell lung cancer

The former is a calculated risk that many researchers accept with the understanding that BUDs include a safety margin
