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doi: 10.1016/j.celrep.2016.05.009 26

[DOI] [PMC free article] [PubMed] [Google Scholar] 375.Yuan, T

55 Apart from the calcium-dependent eNOS activation, exercise also stimulates hormone and growth factor secretions such as norepinephrine (NE) and vascular endothelial growth factor (VEGF), which may bind to 3-AR and VEGFR in endothelial cells and further activate PI3K/AKT signaling and subsequent eNOS phosphorylation

Some people need weekly injections for 4 weeks, followed by maintenance doses
