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In response to oxidative stress, Nrf2 is liberated from the inactive state and then translocated into the nucleus, promoting the expression of antioxidant enzymes by binding to the antioxidant response element [28]

A clear example of this relationship can be observed after the administration of tocilizumab, an IL-6 receptor antagonist that restores the number and cytotoxic activity of CD4 and CD8 T lymphocytes (145)

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Ferlay J, Colombet M, Soerjomataram I, Parkin DM, Pieros M, Znaor A, Bray F (2021) Cancer statistics for the year 2020: an overview
