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Treatments with a family of lipid-lowering drugs known as fibrates (e.g., fenofibrate, bezofibrate) have been associated with an increased excretion of betaine in the urine and a rise in homocysteine concentration in the blood of patients with diabetes mellitus or metabolic syndrome (125, 126)

4 Prevalence, classification, and mechanisms of action of anabolicandrogenic substances Although a uniform classification of anabolicandrogenic substances (AAS) has not been formally established, in practice a functional division based on chemical structure, pharmacokinetics, and route of administration is commonly applied, as illustrated in Figure 1

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It is reported that higher ROS levels decrease maturation by affecting the COC, and also decreases embryo development and blastocyst fragmentation [75]