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Furthermore, it has exhibited the ability to reverse TGF-1-induced epithelial-mesenchymal transition (EMT) in human peritoneal mesothelial cells (HPMC) (123) and pulmonary vascular remodeling induced by pulmonary arterial hypertension (PAH) [191]
Both in vitro and in vivo studies showed that overexpression of TH, a rate-limiting enzyme in dopamine biosynthesis, induces degeneration of dopaminergic neurons [42, 43]
