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A root symbol is very much encouraged by the Human Gene Nomenclature Committee (HGNC) as the basis for a hierarchical series of genes (eg for the ABC family, subfamily A, ABCA1, ABCA2, ABCA3, ABCA4 ) that are either the result of evolutionary divergence of an ancient ancestral gene, or have conserved functions -- via pathways, interactions or protein domains

PubMed Central , Psychiatry Research

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however, modern studies show that this may be due to fixation-based artifacts that alter mitochondrial localization [86,87,88,89]