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Receptor Sensitivity: The Why Behind Cycling Just like insulin receptors can become resistant with constant sugar exposure, peptide receptors can downregulate or desensitize if overstimulated
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Thus muscle derived FGF21 in Cpt1b m/ mice could have anti-inflammatory action locally in the presence of intracellular toxic lipids, and on adipose or possibly other tissues by circulation contributing to the improvement in inflammatory status at the face of constantly elevated systemic lipids
