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Results Influence of A pathology on ferroptosis-related protein levels To investigate the link between A pathology and ferroptosis-related proteins in post-mortem AD brain tissue, we selected mature A plaques in patients from several AD groups (termed AD1, AD2 and AD3 based on the pathology status, as described in Material and Methods section) and compared the expression of ferroptosis-related proteins in the A plaque area with the adjacent area without any plaques (Fig

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Invest Ophthalmol Vis Sci (1980) 19:13752

Two other studies demonstrated that the silica exposure-induced overproduction of ROS is associated with the degradation of the NF-B inhibitor IB- and activation of the NF-B pathway because a pretreatment with NAC decreased a silica-induced accumulation of ROS and inhibited the suppression of IB- [179], or reduced the activation of NF-B [187]