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The main difference lies in their chemical structure and their biological functions

Metabolic engineering to improve provision of the precursor metabolites L-lysine and S -adenosyL-methionine (SAM) may increase de novo production of L-carnitine by the E

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The following is a listed and categorized array of the most significant and common causes: Medical Conditions Diabetes mellitus (most frequent cause globally) Chronic kidney disease (uremia) Liver disease Hypothyroidism Autoimmune disorders (e.g., lupus, rheumatoid arthritis, Sjgren's syndrome) Infections: HIV/AIDS Hepatitis B and C Lyme disease Shingles (post-herpetic neuralgia) Leprosy Nutritional Deficiencies Vitamin B12 deficiency Vitamin B1 (thiamine) deficiency often associated with alcoholism Vitamin B6 toxicity or deficiency Vitamin E and niacin deficiencies Toxins and Medications Chemotherapy medications (e.g., vincristine, cisplatin) Antibiotics (e.g., metronidazole, fluoroquinolones) Excessive alcohol consumption Heavy metals (lead, mercury, arsenic) Industrial toxins (e.g., solvents) Inherited Disorders Charcot-Marie-Tooth disease Hereditary sensory and autonomic neuropathies (HSANs) Trauma or Nerve Compression Carpal tunnel syndrome Herniated disc Sustained pressure on a nerve (e.g., during surgery, cast, or immobilization) Accidents or injuries Other Causes Cancer or tumors compressing nerves Paraneoplastic syndromes (immune responses to tumors) Idiopathic neuropathy no known cause (most common in older adults) Peripheral Neuropathy Diagnosis Diagnosing peripheral neuropathy includes determining the type, cause, and extent of nerve injury