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[DOI] [PubMed] [Google Scholar] 9.Duzel A, Vlainic J, Antunovic M, et al

Excessive methyl supplementation taking too much methylfolate or methyl-B12 for your needs COMT mutations slow breakdown of neurotransmitters, causing buildup when you add more methyls Histamine issues methylation can increase histamine in some people
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As each compound exits the column, it is detected, typically via UV absorbance, and recorded as a peak on a chromatogram