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However, under pathological conditions, mitochondrial dysfunction and protein aggregation (e.g., A, -synuclein) engage in a mutually reinforcing vicious cycle, distinct from a unidirectional causal relationship

This is due to oxidation of the hydrophobic Fc guest to the more hydrophilic Ferrocenium cation (Fc + ) which significantly reduces its interaction with the -CD hydrophobic host cavity 24

The positive transformants were selected on YPD plates with addition of antibiotics geneticin (G418, 4 mg/mL) or hygromycin B (HygB, 1 mg/mL) and verified by DNA sequencing after the integrated gene fragments were amplified by PCR using the corresponding primers and the genomic DNA templates

Perry RR, Mazetta J, Levin M, et al