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ROS attack on functional residues of hemoglobin and glycolytic enzymes such as GAPDH further negatively affects glycolytic fluxes, resulting in the transient activation of the PPP to generate NADPH and counteract storage-induced oxidant stress [53]

The global health status scores showed significant improvement from after 4 weeks of IV Vitamin C therapy as well as significant improvement in physical, emotional, cognitive, and social functioning with fatigue showing the largest improvement (Takahashi 2012)
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