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The market is projected to grow at a compound annual growth rate of 7-10% through 2030
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These mutations are characterized by more severe iron accumulation and earlier onset of disease than Type 1 HH.6 Mutations in HAMP, the gene encoding hepcidin, result in Type 2 HH, a form of juvenile hemochromatosis
However, in DMT1-mutant models, this recycling pathway is disrupted, leading to iron sequestration in lysosomes in a redox-inactive form, thereby lowering cytosolic Fe 2+ levels and suppressing Fenton reactiondriven oxidative stress and ferroptosis
