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Phase 1 study of CB-839, a small molecule inhibitor of glutaminase (GLS) in combination with paclitaxel (Pac) in patients (pts) with triple negative breast cancer (TNBC)

A novel link between chronic inflammation and humanin regulation in children

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This prodrug modification was key to achieving antitumor activity of specific substrate analog Glo1 inhibitors [32,88] (Figure 3)
