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In order to establish the role of AC metabolism in depression risk, we previously [32] leveraged summary-level data from large GWAS (up to ~800,000 samples) and Mendelian randomization analyses to examine the potential reciprocal relationships between circulating levels of 15 ACs and depression

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This allows partially digested food particles, bacterial byproducts, and toxins to cross into the bloodstream, triggering immune reactions and systemic inflammation

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