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(Table 3 ) This limited efficacy was due to the development of anti-CNTF antibodies in these patients [75]

While supplementation with exogenous GSH has shown therapeutic potential on its own, recent findings indicate advantages to combined treatment with other immunomodulatory or anti-infective agents (Vairetti et al., 2021)

However, the reduction of seizure threshold could be attributed to tramadol's putative inhibition of GABA A receptors at high doses (significant inhibition at 100 M)