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Hernandez JL, Woodrow KA (2022) Medical applications of porous biomaterials: features of porosity and tissue-specific implications for biocompatibility

The target sequence GTGTCAGGAGGTGTTTGGAAAG (SEQ ID NO: 2) was inserted into pSUPER vector (Oligoengine, Seattle WA) which drives endogenous production of shRNA under the HI promoter
Variations in the genes for these enzymes have been found to influence alcohol consumption, alcohol-related tissue damage, and alcohol dependence

Current CED trials underway include liposomal irinotecan in high-grade gliomas (NCT02022644) and MDNA55 (an interleukin 4 receptor targeting toxin) in recurrent GBM (NCT02858895)
