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Given the central role of GPX4 in inhibiting lipid peroxidation, preventing ferroptosis, and maintaining the structural integrity of cellular and mitochondrial membranes (Stockwell et al., 2017

Due to its negative charge, N-acetylcysteine entrance in the lens epithelial cells is challenged

Werler MM, Mitchell AA, Hernndez-Daz S, Honein MA

A wide range of etiologies for PIH exists including infections such as dermatophytoses or viral exanthems, allergic reactions such as those from insect bites or a contact dermatitis, papulosquamous diseases like psoriasis or lichen planus, medication-induced PIH from hypersensitivity reactions, or cutaneous injury from irritants, burns, or cosmetic procedures (Figure 1)