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Realistic expectations are crucial

While the initial Orange Book contained only approved drugs and equivalents, the current Orange Book contains 11 : Approved drug products and therapeutic equivalents Patent and exclusivity information for approved drug products Approved over the counter drug products Drug products approved by CDER (under section 505) but administered by CBER Cumulative list of approved products Importantly, the Orange Book contains only approved drug products regulated by CDER, so tentative approvals and biologics regulated by CBER are not included 12

An RCT by Maladkar et al

The IGF2 receptor is a scavenger receptor, and is, therefore, not involved in mediation of growth or metabolic effects of the IGF family and will not be discussed in the current article