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PMID 26109259 69 Schwab MA, Sauer SW, Okun JG, et al

In yet another preferred embodiment of the invention, the CNS pathology is one of a neuropsychiatric disorders, such as depression (e.g., modified by using brain targeted liposomal mineralocorticoid receptor agonists like fludrocortisone, deoxycorticosterone or aldosterone, thereby reducing peripheral cardiovascular side- effects), autism, anxiety, attention deficit hyperactivity disorder (ADHD), addiction and other substance-related disorders, neuropsychiatric systemic lupus erythematosus, bipolar disorder, eating disorders, schizophrenia, and other psychoses

COX-2: cyclooxygenase-2

Together, these findings demonstrate that targeted suppression of Cck expression within the mPFC is sufficient to reverse SDS-induced anxiety phenotypes in KI mice
