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GAS7b bound to the PS and PIP 3 containing reconstituted liposomes equally well, confirming the relatively low sensitivity to the negatively charged phospholipid species, as also shown by GUV-binding experiments (Fig

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For example, lactate can activate the HIF-1 pathway in microglia to enhance pro-inflammatory cytokine release, while IL-1 can inhibit neuronal PGC-1 expression to impair mitochondrial biogenesis, forming a potential link between peripheral immune metabolic reprogramming and central neuroinflammation and energy deficiency