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Upon mPTP opening, cytochrome c (Cyt c) is released from the mitochondrial intermembrane space into the cytosol, initiating the intrinsic (mitochondrial) apoptotic pathway

BMC Cancer 15:713, 2015

Previously unreported effects of RSL3, such as degradation of mTOR signaling pathway protein, p70S6K, and reduction of p-NPM1 levels were identified in the present study and warrant further investigation
