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Animal studies on BPC-157 have demonstrated a favorable safety profile, with no established LD50 (lethal dose) and no documented organ toxicity, carcinogenicity, or mutagenicity at tested doses

The REDEFINE protocol escalated the dose over 16 weeks (0.25 0.5 1.0 1.7 2.4 mg), so the full pharmacologic dose was not reached until roughly week 17

The cagrilintide with tirzepatide combination targets appetite and satiety through multiple mechanisms but does not include the direct fat-cell targeting that AOD 9604 provides

This is useful in globalized scenarios and edge deployments where there are various endpoints