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There is no known upper limit for how much vitamin B12 a person can take

In addition, being deficient in Se has been associated with a decrease in the variety of microorganisms, which further hinders the absorption and utilization of Se in the metabolism of thyroid hormone

To better understand the relationship between metformin and vitamin B12 deficiency, we should have a good understanding of the nature of vitamin B12, the mechanism of its absorption, and how metformin can decrease its absorption
