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In hypertension, increased vascular 20-HETE production contributes to vasoconstriction and elevated peripheral resistance, and urinary 20-HETE is elevated in salt-sensitive hypertension models

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186 Treatment approaches for PROC The mainstay of treatment for PROC patients encompasses the sequential application of cytotoxic agents, including pegylated liposomal doxorubicin (PLD), gemcitabine, paclitaxel, and topotecan