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FIGURE 4 3.5 FOXO4-DRI inhibits FOXO4-P53 binding and promotes P53 phosphorylation To further elucidate the specific mechanism of FOXO4-DRI in anti-aging, we induced senescence in endothelial cells under OGD conditions and treated these cells either PBS or FOXO4-DRI

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Genome-wide association of hypoxia-inducible factor (HIF)-1 and HIF-2 DNA binding with expression profiling of hypoxia-inducible transcripts *

But valuing innovation properly isn't about charging more - it's about counting what a medicine is genuinely worth: to patients, to the workforce, to a budget that pays far more for late, acute care