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Mutations in the DLG motif disrupt the low-affinity binding of Keap1 with Nrf2, resulting in the stabilization of Nrf2, although the association between Keap1 and Nrf2 through the high-affinity binding site, ETGE, is retained
Bupropion SR vs

Z 1 is H, (C 1 -C 5 ) alkyl, or phenyl optionally substituted with one, two, or three groups of (C 1 -C5) alkyl, (C 1 -C5) alkoxy, (C 1 -C 4 ) thioalkoxy, halogen, nitro, COOR, ONHR, -O(CH 2 ) n COOR, -S(CH 2 ) n COOR, -O(CH 2 ) n CONHR, or - S(CH 2 ) n CONHR wherein n and R are as defined above
