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CoQ10 is a crucial cofactor to produce ATP in the electron transport chain (ETC) (Manzar et al., 2020)

7 Challenges and future directions 7.1 Safety and offtarget effects One major hurdle in leveraging ferroptosis for AML therapy is the potential toxicity to normal tissues, especially hematopoietic stem and immune cells, due to systemic iron overload and lipid peroxidation [38, 160]

Photoaging, a major component of extrinsic aging, induces notable structural changes in the skin, such as shortening and thickening of collagen fibers, damage to elastic fibers, loss of type I collagen, and alterations in the ratio of collagen types within the dermis

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